The effect of integrated management of chemical fertilizers and farmyard manure on crop productivity and profitability in rice-niger cropping sequence was studied at Jorhat, Assam during 2005-2006. Application of 75% recommended dose of fertilizers paste along with 25% N through FYM produced the highest yield and uptake of nutrients for both rice and niger crop. Maximum benefit: cost ratio for the sequence was recorded as 1.95 in treatment receiving75% recommended dose of fertilizers along with 25% N through FYM and biofertilizer based integrated nutrient management package.