Experiments were conducted during rabi and early kharif seasons of 2007-2008 and 2008-09 in farmers fields to find out the effect of major nutrients on yield and nutrient uptake of rice in rice-rice cropping system in ten different mandals of Nellore district of Andhra Pradesh. The results revealed that response of rice crop to the nitrogen alone or in combination with phosphorus and potassium was found to be significant. Application of the three nutrients at their recommended doses of 120-60-40 kg ha^-1 during rabi and early kharif resulted the highest yield and nutrient uptake.