The nature of gene interaction in the inheritance of sixteen yield and seven grain quality traits was studied deploying generation mean analysis following 6 parameter model for parents, F₁, F₂, BC₁ and BC₂ generations of three crosses of rice, during wet season. The additive gene effect was significant for all the characters except florets panicle^-1, grain length, cooked kernel breadth and cooked kernel L/B ratio in IET 6441 × Dudheswar, grain yield plant^-1 in IET 8002 × Basmati 385 and cooked kernel length in IET 8002 × Sambamahsuri, while dominance effect was significant for all the characters except days to 50% flowering, panicle length, florets panicle^-1 and kernel length in IET 6441 × Dudheswar, except for total tillers plant^-1, productive tillers plant^-1, panicle length, florets panicle^-1, filled grains panicle-1, floret fertility, 1000 seed weight, grain yield plant-1, harvest index and cooked kernel L/B ratio in the cross IET 8002 × Basmati 385 and except for panicle length, panicle weight, florets panicle^-1, filled grains panicle^-1, floret fertility, grain weight panicle-1, grain yield plant^-1. Duplicate epistasis played an important role in the inheritance of all the yield and quality related traits except days to 50% flowering, panicle length, florets panicle^-1 and kernel length in IET 6441 × Dudheswar.