Field trials were conducted during 2012 and 2013 at Agricultural College and Research Institute, Madurai and in a farmer's holding at Kallandhiri village, Melur Block of Madurai District respectively to evaluate the efficacy of a pre mixture insecticide sulfoxaflor 3.75 + chlorpyriphos 37.5 SE against rice leaf folder and natural enemy (Coccinellids) revealed that the test compound at 516 and 619 g a.i./ha was highly effective in reducing leaf folder incidence (71.2 to 80.2 per cent reduction over control during the period of study) and in case of coccinellids, negligible population reduction were noticed at 516 and 619 g a.i/ha (4.3 to 4.7/hill) when compared to untreated check (5.7 to 6.3/hill). The check insecticides like sulfoxaflor, buprofezin, chlorantraniliprole and chlorpyriphos were observed to be less effective than the test compounds.